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In the liver, S1PR2 activates pro-insulin signaling through enhancing insulin-degrading enzyme (IDE), thereby potentially alleviating insulin resistance associated with T2DM and AD based on animal mechanistic studies (Vettorazzi et al., 2017

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The increased levels of GLUT4 in the plasma membrane stimulate glucose uptake, promoting glucose homeostasis (3638)

SIRT3-AMP-Activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction